Dexrazoxane protects the heart from acute doxorubicin‐induced QT prolongation: a key role for<i>I</i><sub>Ks</sub>

200964 citationsJournal Article

Authors

Joffrey Ducroq · Endometriosis

Hamid Moha ou Maati · Université de Poitiers

Stéphanie Guilbot

Stephen Dilly · APT Therapeutics (United States)

Elisabeth Laemmel · Université Paris Cité

Catherine Pons-Himbert · Computer Emergency Response Team

JF Faivre · Université de Poitiers

Abstract

Doxorubicin acutely prolonged the QT interval in guinea-pig heart by selective I(Ks) blockade. This effect was prevented by dexrazoxane. This result is important because it illustrates the danger of neglecting I(Ks) in favour of hERG screening alone, for early preclinical testing for possible induction of torsade de pointes.

Topics & Keywords

Cardiac electrophysiology and arrhythmias Ion channel regulation and function Electron Spin Resonance Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: British Journal of Pharmacology

Volume 159, Issue 1, pp. 93-101

DOI: 10.1111/j.1476-5381.2009.00371.x

Field-Weighted Citation Impact: 3.16