Growth/Differentiation Factor-5 (GDF-5) and Skeletal Development

2001167 citationsJournal Article

Authors

Philippa H. Francis‐West · Biologie du Développement et Cellules Souches

Abstract

These studies show that GDF-5 acts at two stages of skeletal development and by two distinct mechanisms. First, GDF-5 promotes the initial stages of chondrogenesis by promoting cell adhesion, which is consistent with the expression of Gdf-5 in the cartilage condensation. Second, GDF-5 can increase the size of the skeletal elements by increasing proliferation within the epiphyseal cartilage adjacent to its expression within the joint interzone.

Topics & Keywords

TGF-β signaling in diseases Bone fractures and treatments Neurogenetic and Muscular Disorders Research

Publication Details

Published in: Journal of Bone and Joint Surgery

Volume 83, Issue Pt 1, pp. S1-23–S1–30

DOI: 10.2106/00004623-200100001-00004

Field-Weighted Citation Impact: 1.50

Command Palette

Growth/Differentiation Factor-5 (GDF-5) and Skeletal Development

Authors

Abstract

Topics & Keywords

Publication Details