IL-17A and the Promotion of Neutrophilia in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

2015106 citationsJournal Article

Authors

Abraham B. Roos · Lund University

Sanjay Sethi · VA Western New York Healthcare System

Jake K. Nikota · St. Luke's Hospital

Catherine Wrona · VA Western New York Healthcare System

Michael G. Dorrington · St. Luke's Hospital

Caroline Sandén · Lund University

Carla M. T. Bauer ·

Abstract

IL-17A is induced during NTHi-associated AECOPD. Functionally, IL-1R1-dependent IL-17A is required for NTHi-exacerbated pulmonary neutrophilia induced by cigarette smoke. Targeting IL-17A in AECOPD may thus be beneficial to reduce neutrophil recruitment to the airways.

Topics & Keywords

Asthma and respiratory diseases Pediatric health and respiratory diseases Chronic Obstructive Pulmonary Disease (COPD) Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Respiratory and Critical Care Medicine

Volume 192, Issue 4, pp. 428-437

DOI: 10.1164/rccm.201409-1689oc

Field-Weighted Citation Impact: 7.54