Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers

2015192 citationsJournal Articlegold Open Access

Authors

Sarah Voisin · Uppsala University

Markus Sällman Almén · Uppsala University

Galina Yurevna Zheleznyakova · Uppsala University

Lina Lundberg · Uppsala University

Sanaz Zarei · Uppsala University

Sandra Castillo · Uppsala University

Fia Ence Eriksson ·

Abstract

Our results strongly suggest that many obesity-associated SNPs are associated with proximal gene regulation, which was reflected by association of obesity risk allele genotypes with differential DNA methylation. This study highlights the importance of DNA methylation and other chromatin marks as a way to understand the molecular basis of genetic variants associated with human diseases and traits.

Topics & Keywords

Epigenetics and DNA Methylation RNA modifications and cancer Genetic Associations and Epidemiology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Genome Medicine

Volume 7, Issue 1, pp. 103-103

DOI: 10.1186/s13073-015-0225-4

Field-Weighted Citation Impact: 6.93