Attenuation of Colitis by Serum-Derived Bovine Immunoglobulin/Protein Isolate in a Defined Microbiota Mouse Model

201537 citationsJournal Articlehybrid Open Access

Authors

Abigail Henderson

Meghan Wymore Brand · Iowa State University

Ross Darling · Iowa State University

Kenneth J. Maas · Cara Therapeutics (United States)

Christopher J. Detzel

Jesse M. Hostetter · Iowa State University

Michael J. Wannemuehler · Iowa State University

Eric Weaver

Abstract

Oral administration of SBI attenuated clinical signs of LF82/DSS-induced colitis in mice. The data are consistent with the hypothesis that SBI immunoglobulin binding of bacterial antigens in the intestinal lumen may inhibit the inflammatory cascades that contribute to IBD, thus attenuating DSS-induced colitis.

Topics & Keywords

Animal health and immunology Helicobacter pylori-related gastroenterology studies Clostridium difficile and Clostridium perfringens research

UN Sustainable Development Goals

Life in Land

Publication Details

Published in: Digestive Diseases and Sciences

Volume 60, Issue 11, pp. 3293-3303

DOI: 10.1007/s10620-015-3726-5

Field-Weighted Citation Impact: 8.20