Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling.

2002777 citationsJournal Article

Authors

Jennifer A. Tuxhorn · Baylor College of Medicine

Gustavo E. Ayala · Baylor College of Medicine

Megan J. Smith · Baylor College of Medicine

Vincent C. Smith · Baylor College of Medicine

Truong D. Dang · Baylor College of Medicine

David R. Rowley · Baylor College of Medicine

Abstract

The stromal microenvironment in human prostate cancer is altered compared with normal stroma and exhibits features of a wound repair stroma. Reactive stroma is composed of myofibroblasts and fibroblasts stimulated to express extracellular matrix components. Reactive stroma appears to be initiated during PIN and evolve with cancer progression to effectively displace the normal fibromuscular stroma. These studies and others suggest that TGF-beta1 is a candidate regulator of reactive stroma during prostate cancer progression.

Topics & Keywords

Peptidase Inhibition and Analysis Protease and Inhibitor Mechanisms Prostate Cancer Treatment and Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PubMed

Volume 8, Issue 9, pp. 2912-23

Field-Weighted Citation Impact: 9.00