VEGF-initiated blood-retinal barrier breakdown in early diabetes.

2001508 citationsJournal Article

Authors

Tamim Qaum · Boston Children's Hospital

Qingguo Xu

Haroutioun Hasséssian

Stanley J. Wiegand

J.S. Rudge

George D. Yancopoulos

A.P. Adamis

Abstract

Early blood-retinal barrier breakdown in experimental diabetes is VEGF dependent and is restricted, in part, to the venules and capillaries of the superficial inner retinal vasculature. VEGF inhibition should prove a useful therapeutic approach in the treatment of early diabetic blood-retinal barrier breakdown.

Topics & Keywords

Retinal Diseases and Treatments Glaucoma and retinal disorders Barrier Structure and Function Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PubMed

Volume 42, Issue 10, pp. 2408-13

Field-Weighted Citation Impact: 14.66