P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite

2015175 citationsJournal Articlegold Open Access

Authors

Liang Feng · Southern Medical University

Yizhao Chen · Southern Medical University

Rui Ding · First People’s Hospital of Jingmen

Zhenghao Fu · Third Affiliated Hospital of Southern Medical University

Shuo Yang · Central Hospital of Zibo

Xinqing Deng · Jinan University

Jun Zeng ·

Abstract

Our findings implicate that P2X7R exacerbated inflammatory progression and brain damage in ICH rats possibly via NLRP3 inflammasome-dependent IL-1β/IL-18 release and neutrophil infiltration. ONOO(-), a potential downstream signaling molecule of P2X7R, may play a critical role in triggering NLRP3 inflammasome activation.

Topics & Keywords

Intracerebral and Subarachnoid Hemorrhage Research Neurosurgical Procedures and Complications Heme Oxygenase-1 and Carbon Monoxide

Publication Details

Published in: Journal of Neuroinflammation

Volume 12, Issue 1, pp. 186-186

DOI: 10.1186/s12974-015-0409-2

Field-Weighted Citation Impact: 11.99

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P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite

Authors

Abstract

Topics & Keywords

Publication Details