Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice

2015151 citationsJournal Articlehybrid Open Access

Authors

Emily M. Rocha · Harvard University

Gaynor A. Smith · Harvard University

Eric Park · Takeda (United States)

Hongmei Cao · Takeda (United States)

Anne-Renee Graham · Takeda (United States)

Eilish Brown · Takeda (United States)

Jesse R. McLean ·

Abstract

These data reveal a link between reduced glucocerebrosidase and the development of α-synucleinopathy and pathophysiological abnormalities in mice, and support the development of GCase therapeutics to reduce α-synucleinopathy in PD and related disorders.

Topics & Keywords

Lysosomal Storage Disorders Research Cellular transport and secretion Parkinson's Disease Mechanisms and Treatments

Publication Details

Published in: Antioxidants and Redox Signaling

Volume 23, Issue 6, pp. 550-564

DOI: 10.1089/ars.2015.6307

Field-Weighted Citation Impact: 4.90

Command Palette

Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice

Authors

Abstract

Topics & Keywords

Publication Details