Neuroinflammatory signals enhance the immunomodulatory and neuroprotective properties of multipotent adult progenitor cells

201521 citationsJournal Articlegold Open Access

Authors

Stylianos Ravanidis · Hasselt University

Jeroen F. J. Bogie · Hasselt University

Raf Donders · Hasselt University

David Craeye · Regenesys Business School

Robert W. Mays · Athersys (United States)

Robert Deans · Athersys (United States)

Kristel Gijbels ·

Abstract

Rat MAPC possess immune modulatory and neuroprotective properties which are enhanced in response to neuroinflammatory signals. These findings thereby warrant further research to evaluate MAPC transplantation as a therapeutic approach in diseases with an immunological and neurodegenerative component such as multiple sclerosis.

Topics & Keywords

Mesenchymal stem cell research Neuroinflammation and Neurodegeneration Mechanisms MicroRNA in disease regulation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Stem Cell Research & Therapy

Volume 6, Issue 1, pp. 176-176

DOI: 10.1186/s13287-015-0169-z

Field-Weighted Citation Impact: 1.38