Genotype of <i>UGT1A1</i> and phenotype correlation between Crigler–Najjar syndrome type II and Gilbert syndrome

The serum bilirubin concentration varied continuously from GS to CN-2 depending on genotypes. Because of the combination of the mutations and polymorphisms, many patients showed intermediate serum bilirubin concentration between two syndromes. Clinically, it is difficult to distinguish clearly between the two syndromes.