Ketone bodies mediate antiseizure effects through mitochondrial permeability transition

2015185 citationsJournal Articlegreen Open Access

Authors

Do Young ‍Kim · Barrow Neurological Institute

Kristina A. Simeone · Creighton University

Timothy A. Simeone · Creighton University

Jignesh D. Pandya · University of Kentucky

Julianne Wilke · Barrow Neurological Institute

Younghee Ahn · University of Calgary

James W. Geddes ·

Abstract

The present data reveal the first direct link between mPT and seizure control, and provide a potential mechanistic explanation for the KD. Given that mPT is increasingly being implicated in diverse neurological disorders, our results suggest that metabolism-based treatments and/or metabolic substrates might represent a worthy paradigm for therapeutic development.

Topics & Keywords

Diet and metabolism studies Metabolism and Genetic Disorders Mitochondrial Function and Pathology

Publication Details

Published in: Annals of Neurology

Volume 78, Issue 1, pp. 77-87

DOI: 10.1002/ana.24424

Field-Weighted Citation Impact: 11.88

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Ketone bodies mediate antiseizure effects through mitochondrial permeability transition

Authors

Abstract

Topics & Keywords

Publication Details