A Multicenter Randomized Trial of Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis

2015263 citationsJournal Article

Authors

Joel M. Dulhunty · The University of Queensland

Jason A. Roberts · The University of Queensland

Joshua S. Davis · John Hunter Hospital

S. A. R. Webb · The University of Western Australia

Rinaldo Bellomo · Austin Hospital

Charles D. Gomersall · Chinese University of Hong Kong

Charudatt Shirwadkar

Abstract

In critically ill patients with severe sepsis, there was no difference in outcomes between β-lactam antibiotic administration by continuous and intermittent infusion. Australian New Zealand Clinical Trials Registry number (ACT RN12612000138886).

Topics & Keywords

Antibiotics Pharmacokinetics and Efficacy Pneumonia and Respiratory Infections Antibiotic Resistance in Bacteria

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: American Journal of Respiratory and Critical Care Medicine

Volume 192, Issue 11, pp. 1298-1305

DOI: 10.1164/rccm.201505-0857oc

Field-Weighted Citation Impact: 26.76