New Nomenclature for the Human Tissue Kallikrein Gene Family

2000179 citationsJournal Articlebronze Open Access

Authors

Eleftherios P. Diamandis · Mount Sinai Hospital

George M. Yousef · University of Toronto

Judith A. Clements · Queensland University of Technology

Linda K. Ashworth · Lawrence Livermore National Laboratory

Shigetaka Yoshida · Nara Institute of Science and Technology

Torbjörn Egelrud · Umeå University

Peter S. Nelson

Abstract

1.02-1.55 (mean 1.30; SD 0.18), compatible with heterozygosity. No individuals homozygous for the Cys282Tyr mutation were identified. To validate the method for detection of the homozygous mutant genotype, the assay was performed on a blood sample from a known homozygote. The NSS ratios for this individual, in two evaluations, were 9.1 and 7.4, within the predicted range.

Topics & Keywords

Coagulation, Bradykinin, Polyphosphates, and Angioedema Renal and related cancers Hemophilia Treatment and Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Chemistry

Volume 46, Issue 11, pp. 1855-1858

DOI: 10.1093/clinchem/46.11.1855

Field-Weighted Citation Impact: 14.60