Randomized Comparison of Fluorouracil Plus Cisplatin Versus Hydroxyurea as an Adjunct to Radiation Therapy in Stage IIB-IVA Carcinoma of the Cervix With Negative Para-Aortic Lymph Nodes: A Gynecologic Oncology Group and Southwest Oncology Group Study

19991,532 citationsJournal Articlebronze Open Access

Authors

Charles W. Whitney

William T. Sause · University of North Carolina at Chapel Hill

Brian N. Bundy · Roswell Park Comprehensive Cancer Center

John H. Malfetano · University of North Carolina at Chapel Hill

Edward V. Hannigan · Thomas Jefferson University

Wesley C. Fowler

Daniel L. Clarke‐Pearson · Duke University

Shu‐Yuan Liao

Abstract

This study demonstrates that for patients with locally advanced carcinoma of the cervix, the combination of 5-FU and CF with RT offers patients better PFS and overall survival than HU, and with manageable toxicity.

Topics & Keywords

Endometrial and Cervical Cancer Treatments Colorectal and Anal Carcinomas Ovarian cancer diagnosis and treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Clinical Oncology

Volume 17, Issue 5, pp. 1339-1339

DOI: 10.1200/jco.1999.17.5.1339

Field-Weighted Citation Impact: 52.11