Glucagon‐like peptide‐1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high‐fat diet in nonalcoholic steatohepatitis

2011395 citationsJournal Article

Authors

Gianluca Svegliati‐Baroni · Marche Polytechnic University

S. Saccomanno · Marche Polytechnic University

C. Rychlicki · Marche Polytechnic University

Laura Agostinelli · Marche Polytechnic University

Samuele De Minicis · Marche Polytechnic University

C. Candelaresi · Marche Polytechnic University

G. Faraci

Abstract

GLP-1 has a direct effect on hepatocytes, by activating genes involved in fatty acid β-oxidation and insulin sensitivity. GLP-1 analogues could be a promising treatment approach to improve hepatic insulin resistance in patients with NAFLD/NASH.

Topics & Keywords

Liver Disease Diagnosis and Treatment Pancreatic function and diabetes Diet, Metabolism, and Disease

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Liver International

Volume 31, Issue 9, pp. 1285-1297

DOI: 10.1111/j.1478-3231.2011.02462.x

Field-Weighted Citation Impact: 18.36