In vivo intervertebral disc regeneration using stem cell–derived chondroprogenitors

200972 citationsJournal Article

Authors

Hormoz Sheikh · University of California, Los Angeles

Karen Zakharian · Providence Regional Medical Center Everett

Ramiro Perez De La Torre · Michigan Head and Spine Institute

Christopher Facek · Oakland University

Adrian A. Vasquez · Oakland University

G. Rasul Chaudhry · Oakland University

David M. Svinarich

Abstract

This study illustrates a reproducible percutaneous model for studying disc degeneration. New notochordal cell populations were seen in degenerated discs injected with ESCs. The lack of immune response to a xenograft of mouse cells in an immunocompetent rabbit model may suggest an as yet unrecognized immunoprivileged site within the intervertebral disc space.

Topics & Keywords

Spine and Intervertebral Disc Pathology Musculoskeletal pain and rehabilitation Tendon Structure and Treatment

UN Sustainable Development Goals

Life in Land

Publication Details

Published in: Journal of Neurosurgery Spine

Volume 10, Issue 3, pp. 265-272

DOI: 10.3171/2008.12.spine0835

Field-Weighted Citation Impact: 2.69