Continued (5-Year) Followup of A Randomized Clinical Study Comparing Antireflux Surgery and Omeprazole in Gastroesophageal Reflux Disease

In this randomized multicenter trial with a 5-year followup, we found antireflux surgery to be more effective than omeprazole in controlling gastroesophageal reflux disease as measured by the treatment failure rates. But if the dose of omeprazole was adjusted in case of relapse, the two therapeutic strategies reached levels of efficacy that were not statistically different.