In vivo validation of 3'deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) as a proliferation imaging tracer in humans: correlation of [(18)F]FLT uptake by positron emission tomography with Ki-67 immunohistochemistry and flow cytometry in human lung tumors.

2002299 citationsJournal Article

Authors

Hubert Vesselle · University of Washington

John R. Grierson

Abstract

FLT PET may be used to noninvasively assess proliferation rates of lung masses in vivo. Therefore, FLT PET may play a significant role in the evaluation of indeterminate pulmonary lesions, in the prognostic assessment of resectable NSCLC, and possibly in the evaluation of NSCLC response to chemotherapy.

Topics & Keywords

Medical Imaging Techniques and Applications Lung Cancer Treatments and Mutations Radiopharmaceutical Chemistry and Applications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PubMed

Volume 8, Issue 11, pp. 3315-23

Field-Weighted Citation Impact: 13.93