TGF-β1 induces human alveolar epithelial to mesenchymal cell transition (EMT)

2005737 citationsJournal Articlegold Open Access

Authors

Hidenori Kasai · LifeArc

Jeremy Allen · University of Salford

Roger M. Mason · Hammersmith Hospital

Takashi Kamimura · Teijin (Japan)

Zhi Zhang · LifeArc

Abstract

Our study shows that TGF-beta1 induces A549 alveolar epithelial cells to undergo EMT via Smad2 activation. Our data support the concept of EMT in lung epithelial cells, and suggest the need for further studies to investigate the phenomenon.

Topics & Keywords

Neonatal Respiratory Health Research Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis Connective Tissue Growth Factor Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Respiratory Research

Volume 6, Issue 1, pp. 56-56

DOI: 10.1186/1465-9921-6-56

Field-Weighted Citation Impact: 16.71