Deleted in liver cancer 2 suppresses cell growth via the regulation of the Raf-1-ERK1/2-p70S6K signalling pathway

201026 citationsJournal Articlebronze Open Access

Authors

Thomas Leung · CSY China-International Hepatitis Research Foundation

Judy Wai Ping Yam · Chinese University of Hong Kong

Irene Oi‐Lin Ng · CSY China-International Hepatitis Research Foundation

Abstract

Our data show that DLC2 inhibits the activity of Raf-1-ERK1/2-p70S6K via its RhoGAP function, resulting in the suppression of cell growth. Further studies on the molecular signalling between DLC2 and p70S6K may provide an insight into its growth suppressor function.

Topics & Keywords

Protein Kinase Regulation and GTPase Signaling Cellular Mechanics and Interactions Hippo pathway signaling and YAP/TAZ

Publication Details

Published in: Liver International

Volume 30, Issue 9, pp. 1315-1323

DOI: 10.1111/j.1478-3231.2010.02307.x

Field-Weighted Citation Impact: 1.06

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Deleted in liver cancer 2 suppresses cell growth via the regulation of the Raf-1-ERK1/2-p70S6K signalling pathway

Authors

Abstract

Topics & Keywords

Publication Details