OSTEOGENIC ACTIVITY OF THE FOURTEEN TYPES OF HUMAN BONE MORPHOGENETIC PROTEINS (BMPS)

20031,010 citationsJournal Article

Authors

Hongwei Cheng · University of Chicago Medical Center

Wei Jiang · Baidu (China)

Frank M. Phillips · Psyadon Pharmaceuticals (United States)

Rex C. Haydon · Peng Huanwu Center for Fundamental Theory

Ying Peng · Michigan Department of Education

Lan Zhou · Hue University

Hue H. Luu

Abstract

A comprehensive analysis of the osteogenic activity of fourteen types of BMPs in osteoblastic progenitor cells was conducted. Our results suggest an osteogenic hierarchical model in which BMP-2, 6, and 9 may play an important role in inducing osteoblast differentiation of mesenchymal stem cells. In contrast, most BMPs are able to stimulate osteogenesis in mature osteoblasts.

Topics & Keywords

Bone fractures and treatments Bone Tissue Engineering Materials TGF-β signaling in diseases

Publication Details

Published in: Journal of Bone and Joint Surgery

Volume 85, Issue 8, pp. 1544-1552

DOI: 10.2106/00004623-200308000-00017

Field-Weighted Citation Impact: 18.07

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OSTEOGENIC ACTIVITY OF THE FOURTEEN TYPES OF HUMAN BONE MORPHOGENETIC PROTEINS (BMPS)

Authors

Abstract

Topics & Keywords

Publication Details