Using Pravastatin to Improve the Vascular Reactivity in a Mouse Model of Soluble Fms-Like Tyrosine Kinase-1–Induced Preeclampsia

2010125 citationsJournal Article

Authors

Maged M. Costantine · The University of Texas Medical Branch at Galveston

Esther Tamayo · The University of Texas Medical Branch at Galveston

Fangxian Lu · The University of Texas Medical Branch at Galveston

Egle Bytautiene · The University of Texas Medical Branch at Galveston

Monica Longo · The University of Texas Medical Branch at Galveston

Gary D.V. Hankins · The University of Texas Medical Branch at Galveston

Abstract

Pravastatin improved the vascular reactivity in this murine model of preeclampsia by decreasing sFlt-1 levels. Statins should be evaluated for the prevention of the vascular abnormalities of preeclampsia.

Topics & Keywords

Pregnancy and preeclampsia studies Birth, Development, and Health Systemic Lupus Erythematosus Research

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Obstetrics and Gynecology

Volume 116, Issue 1, pp. 114-120

DOI: 10.1097/aog.0b013e3181e10ebd

Field-Weighted Citation Impact: 6.21