Developments in Asymmetric Hydrogenation from an Industrial Perspective

2007304 citationsJournal Article

Authors

Hideo Shimizu · Takasago (Japan)

Izuru Nagasaki · Takasago (Japan)

Kazuhiko Matsumura · Takasago (Japan)

Noboru Sayo · Takasago (Japan)

Takao Saito · Takasago (Japan)

Abstract

Examples of developments in asymmetric hydrogenation from various perspectives, in an effort to improve efficiency, are reported. Discussed in this Account are (1) the improved synthesis of BINAP ligands, (2) the design of SEGPHOS ligands for higher enantioselectivity, (3) a new protocol with fewer reaction steps to synthesize beta-aminoesters, and (4) a novel asymmetric hydrogenation mediated by a copper catalyst.

Topics & Keywords

Asymmetric Hydrogenation and Catalysis Catalysis for Biomass Conversion Carbon dioxide utilization in catalysis

UN Sustainable Development Goals

Industry, innovation and infrastructure

Publication Details

Published in: Accounts of Chemical Research

Volume 40, Issue 12, pp. 1385-1393

DOI: 10.1021/ar700101x

Field-Weighted Citation Impact: 6.03