Peripheral and Central GLP-1 Receptor Populations Mediate the Anorectic Effects of Peripherally Administered GLP-1 Receptor Agonists, Liraglutide and Exendin-4

2011338 citationsJournal Articlebronze Open Access

Authors

Scott E. Kanoski · University of Pennsylvania

Samantha M. Fortin · University of Pennsylvania

Harvey J. Grill · University of Pennsylvania

Matthew R. Hayes · University of Pennsylvania

Abstract

Food intake suppression after peripheral administration of exendin-4 and liraglutide is mediated by activation of GLP-1R expressed on vagal afferents as well as direct CNS GLP-1R activation.

Topics & Keywords

Diabetes Treatment and Management Regulation of Appetite and Obesity Neuropeptides and Animal Physiology

Publication Details

Published in: Endocrinology

Volume 152, Issue 8, pp. 3103-3112

DOI: 10.1210/en.2011-0174

Field-Weighted Citation Impact: 15.63

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Peripheral and Central GLP-1 Receptor Populations Mediate the Anorectic Effects of Peripherally Administered GLP-1 Receptor Agonists, Liraglutide and Exendin-4

Authors

Abstract

Topics & Keywords

Publication Details