Epigenetics in Cancer

20083,623 citationsReviewgreen Open Access

Authors

Manel Esteller · Centro de Investigación del Cáncer

Abstract

Gene transcription can be activated or inhibited by a reversible modification of the gene; this modification is termed an epigenetic change. This account of epigenetics in cancer reviews the mechanisms and consequences of epigenetic changes in cancer cells and concludes with the implications of these changes for the diagnosis, prognosis, and treatment of cancer.

Topics & Keywords

Epigenetics and DNA Methylation Histone Deacetylase Inhibitors Research Genomics and Chromatin Dynamics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 358, Issue 11, pp. 1148-1159

DOI: 10.1056/nejmra072067

Field-Weighted Citation Impact: 111.72