HPV Vaccine against Anal HPV Infection and Anal Intraepithelial Neoplasia

2011935 citationsJournal Article

Authors

Joel M. Palefsky · University of California, San Francisco

Anna R. Giuliano · Moffitt Cancer Center

Stephen E. Goldstone · Icahn School of Medicine at Mount Sinai

Edson Duarte Moreira

Carlos Aranda · Instituto Nacional de Salud Pública

Heiko Jessen

Richard J. Hillman · University of Sydney

Daron Ferris

Abstract

Use of the qHPV vaccine reduced the rates of anal intraepithelial neoplasia, including of grade 2 or 3, among men who have sex with men. The vaccine had a favorable safety profile and may help to reduce the risk of anal cancer. (Funded by Merck and the National Institutes of Health; ClinicalTrials.gov number, NCT00090285.).

Topics & Keywords

Cervical Cancer and HPV Research Colorectal and Anal Carcinomas Lymphadenopathy Diagnosis and Analysis

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 365, Issue 17, pp. 1576-1585

DOI: 10.1056/nejmoa1010971

Field-Weighted Citation Impact: 49.35