Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

20091,108 citationsJournal Articlebronze Open Access

Authors

Daniel D. Von Hoff · Translational Genomics Research Institute

Patricia LoRusso · The Barbara Ann Karmanos Cancer Institute

Charles M. Rudin · Johns Hopkins University

Josina C. Reddy

Robert L. Yauch

Raoul Tibes · Translational Genomics Research Institute

Glen J. Weiss · Translational Genomics Research Institute

Mitesh J. Borad

Abstract

GDC-0449, an orally active small molecule that targets the hedgehog pathway, appears to have antitumor activity in locally advanced or metastatic basal-cell carcinoma. (ClinicalTrials.gov number, NCT00607724.)

Topics & Keywords

Hedgehog Signaling Pathway Studies Cancer and Skin Lesions Genetic and rare skin diseases.

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 361, Issue 12, pp. 1164-1172

DOI: 10.1056/nejmoa0905360

Field-Weighted Citation Impact: 58.24