Toward Understanding How the Lactone Moiety of Discodermolide Affects Activity

200557 citationsJournal Article

Authors

Simon J. Shaw · University of Pennsylvania

Kurt F. Sundermann · University of Pennsylvania

Mark A. Burlingame · University of Pennsylvania

David C. Myles · University of Pennsylvania

B. Scott Freeze · University of Pennsylvania

Ming Xian · University of Pennsylvania

Ignacio Brouard ·

Abstract

A series of simplified discodermolide analogues have been designed and synthesized in an attempt to understand the role of the lactone ring. These synthetic efforts have led to an unsubstituted butyrolactone 9 being generated, which shows improved activity over the natural product.

Topics & Keywords

Cancer Treatment and Pharmacology Synthetic Organic Chemistry Methods Chemical synthesis and alkaloids

Publication Details

Published in: Journal of the American Chemical Society

Volume 127, Issue 18, pp. 6532-6533

DOI: 10.1021/ja051185i

Field-Weighted Citation Impact: 3.23

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Toward Understanding How the Lactone Moiety of Discodermolide Affects Activity

Authors

Abstract

Topics & Keywords

Publication Details