Functional Assessment of Human Alcohol Dehydrogenase Family in Ethanol Metabolism: Significance of First‐Pass Metabolism

2006121 citationsJournal Article

Authors

S. D. Lee · Animal Technology Institute Taiwan

Gar‐Yang Chau · Taipei Veterans General Hospital

Chung‐Tay Yao · National Defense Medical Center

Chew‐Wun Wu · Taipei Veterans General Hospital

Shih‐Jiun Yin · National Defense Medical Center

Abstract

This work provides just a model, but a strong one, for quantitative assessments of ethanol metabolism in the human liver and stomach. The results indicate that the hepatic-alcohol clearance of ADH1B*2 individuals is higher than that of the ADH1B*1 and those of the ADH1B*3 versus the ADH1B*1 vary depending on sinusoidal ethanol levels. The maximal capacity for potential alcohol first-pass metabolism in the liver is greater than in the stomach.

Topics & Keywords

Alcohol Consumption and Health Effects Pharmacogenetics and Drug Metabolism Metabolism and Genetic Disorders

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Alcoholism Clinical and Experimental Research

Volume 30, Issue 7, pp. 1132-1142

DOI: 10.1111/j.1530-0277.2006.00139.x

Field-Weighted Citation Impact: 3.04