Olfaction and imaging biomarkers in premotor <i>LRRK2</i> G2019S-associated Parkinson disease

201380 citationsJournal Article

Authors

María Sierra · Marqués de Valdecilla University Hospital

Pascual Sánchez‐Juan · Marqués de Valdecilla University Hospital

María Isabel Martínez-Rodríguez · Marqués de Valdecilla University Hospital

Isabel González Aramburu · Marqués de Valdecilla University Hospital

Inés García‐Gorostiaga · Marqués de Valdecilla University Hospital

María Remedios Quirce · Marqués de Valdecilla University Hospital

Abstract

Independently of age at examination, the most frequently altered premotor biomarker in LRRK2 G2019S-associated PD was SN hyperechogenicity, whereas abnormal DaT-SPECT predominated in older, unaffected mutation carriers.

Topics & Keywords

Parkinson's Disease Mechanisms and Treatments Lysosomal Storage Disorders Research Neurological diseases and metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neurology

Volume 80, Issue 7, pp. 621-626

DOI: 10.1212/wnl.0b013e31828250d6

Field-Weighted Citation Impact: 5.70