Hippocampal atrophy rates in Alzheimer disease

2009384 citationsJournal Articlegreen Open Access

Authors

Wouter J.P. Henneman · UK Dementia Research Institute

Jasper D. Sluimer · UK Dementia Research Institute

Josephine Barnes · UK Dementia Research Institute

Wiesje M. van der Flier · UK Dementia Research Institute

Ingrid C. Sluimer · UK Dementia Research Institute

Nick C. Fox · UK Dementia Research Institute

Philip Scheltens

Abstract

Hippocampal measures, especially hippocampal atrophy rate, best discriminate mild cognitive impairment (MCI) from controls. Whole brain atrophy rate discriminates Alzheimer disease (AD) from MCI. Regional measures of hippocampal atrophy are the strongest predictors of progression to AD.

Topics & Keywords

Dementia and Cognitive Impairment Research Alzheimer's disease research and treatments Advanced Neuroimaging Techniques and Applications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neurology

Volume 72, Issue 11, pp. 999-1007

DOI: 10.1212/01.wnl.0000344568.09360.31

Field-Weighted Citation Impact: 10.32