Rotenone, Paraquat, and Parkinson’s Disease

20111,429 citationsJournal Articlediamond Open Access

Authors

Caroline M. Tanner · Parkinson's Institute and Clinical Center

Freya Kamel · National Institutes of Health

G. Webster Ross · VA Pacific Islands Health Care System

Jane A. Hoppin · National Institutes of Health

Samuel M. Goldman · Parkinson's Institute and Clinical Center

Monica Korell · Parkinson's Institute and Clinical Center

Connie Marras

Abstract

PD was positively associated with two groups of pesticides defined by mechanisms implicated experimentally-those that impair mitochondrial function and those that increase oxidative stress-supporting a role for these mechanisms in PD pathophysiology.

Topics & Keywords

Parkinson's Disease Mechanisms and Treatments Biochemical and biochemical processes Paraquat toxicity studies and treatments

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: Environmental Health Perspectives

Volume 119, Issue 6, pp. 866-872

DOI: 10.1289/ehp.1002839

Field-Weighted Citation Impact: 53.60