Differentially methylated CpG island within human XIST mediates alternative P2 transcription and YY1 binding

201450 citationsJournal Articlediamond Open Access

Authors

Andrew Glen Chapman · 3v Geomatics (Canada)

Allison M. Cotton · University of British Columbia

Angela D. Kelsey · University of British Columbia

Carolyn J. Brown · University of British Columbia

Abstract

The differentially methylated DNase hypersensitive site within XIST marks the location of an alternative promoter, P2, that generates a transcript of unknown function as it lacks the A repeats that are critical for silencing. In addition, this region binds YY1 on the unmethylated inactive X chromosome, and depletion of YY1 untethers the XIST RNA as well as decreasing transcription of XIST.

Topics & Keywords

Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities Cancer-related molecular mechanisms research Genomics and Chromatin Dynamics

UN Sustainable Development Goals

Life below water

Publication Details

Published in: BMC Genetics

Volume 15, Issue 1, pp. 89-89

DOI: 10.1186/s12863-014-0089-4

Field-Weighted Citation Impact: 3.27