Distinct Effects of Δ9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing

2009457 citationsJournal Articlebronze Open Access

Authors

Paolo Fusar‐Poli · Wellcome Centre for Human Neuroimaging

José A. Crippa · King's College London

Sagnik Bhattacharyya

Stefan Borgwardt · King's College London

Paul Allen

Rocı́o Martı́n-Santos · King's College London

Marc L. Seal · King's College London

Simon A. Surguladze

Abstract

Delta9-Tetrahydrocannabinol and CBD had clearly distinct effects on the neural, electrodermal, and symptomatic response to fearful faces. The effects of CBD on activation in limbic and paralimbic regions may contribute to its ability to reduce autonomic arousal and subjective anxiety, whereas the anxiogenic effects of Delta9-THC may be related to effects in other brain regions.

Topics & Keywords

Cannabis and Cannabinoid Research Sleep and Wakefulness Research Neuroscience of respiration and sleep

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Archives of General Psychiatry

Volume 66, Issue 1, pp. 95-95

DOI: 10.1001/archgenpsychiatry.2008.519

Field-Weighted Citation Impact: 24.95