Versatile Virus-Like Particle Carrier for Epitope Based Vaccines

2010200 citationsJournal Articlegold Open Access

Authors

Alain C. Tissot

Regīna Renhofa · Latvian Biomedical Research and Study Centre

Nicole Schmitz

Indulis Cielēns · Latvian Biomedical Research and Study Centre

E. Meijerink

Velta Ose · Latvian Biomedical Research and Study Centre

Gary T. Jennings

Philippe Saudan

Paul Pumpens · Latvian Biomedical Research and Study Centre

Abstract

AP205 VLPs are therefore a very efficient and new vaccine system, suitable for complex and long epitopes, of up to at least 55 amino acid residues in length. AP205 VLPs confer a high immunogenicity to displayed epitopes, as shown by inhibition of endogenous GnRH and protective immunity against influenza infection.

Topics & Keywords

Monoclonal and Polyclonal Antibodies Research vaccines and immunoinformatics approaches Glycosylation and Glycoproteins Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 5, Issue 3, pp. e9809-e9809

DOI: 10.1371/journal.pone.0009809

Field-Weighted Citation Impact: 10.95