Modulation of Sympathetic Coronary Vasoconstriction by Cardiac Renin-Angiotensin System in Human Coronary Heart Disease

200025 citationsJournal Article

Authors

Antonio Saino · University of Milano-Bicocca

G. Pomidossi · University of Milano-Bicocca

R Perondi · University of Milano-Bicocca

Alberto Morganti · University of Milano-Bicocca

Lucia Turolo · University of Milano-Bicocca

Giuseppe Mancia · University of Milano-Bicocca

Abstract

In patients with coronary artery disease, an attenuation of sympathetic coronary vasoconstriction can be obtained by reducing cardiac angiotensin II formation without involving circulating angiotensin II. This suggests a role of the tissue renin-angiotensin system in modulating autonomic cardiac drive in humans.

Topics & Keywords

Heart Rate Variability and Autonomic Control Cardiovascular and exercise physiology Blood Pressure and Hypertension Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 101, Issue 19, pp. 2277-2283

DOI: 10.1161/01.cir.101.19.2277

Field-Weighted Citation Impact: 1.74