Toll-like Receptor 4 Polymorphisms and Atherogenesis

20021,022 citationsJournal Articlebronze Open Access

Authors

Stefan Kiechl · University Clinic of Traumatology

Eva Lorenz

Markus Reindl · University Clinic of Traumatology

Christian J. Wiedermann · University Clinic of Traumatology

Friedrich Oberhollenzer · Krankenhaus Bruneck

Enzo Bonora · University of Verona

Johann Willeit · University Clinic of Traumatology

Abstract

The Asp299Gly TLR4 polymorphism, which attenuates receptor signaling and diminishes the inflammatory response to gram-negative pathogens, is associated with a decreased risk of atherosclerosis. This finding is consistent with the hypothesis that innate immunity may play a part in atherogenesis.

Topics & Keywords

Immune Response and Inflammation Inflammasome and immune disorders Adipokines, Inflammation, and Metabolic Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 347, Issue 3, pp. 185-192

DOI: 10.1056/nejmoa012673

Field-Weighted Citation Impact: 23.87