Targeting Eukaryotic Translation in Mesothelioma Cells with an eIF4E-Specific Antisense Oligonucleotide

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Authors

Blake A. Jacobson · University of Minnesota

Saritha C. Thumma · University of Minnesota

Joseph Jay-Dixon · University of Minnesota

Manish R. Patel · University of Minnesota

K. Dubear Kroening · Fox Valley Technical College

Marian G. Kratzke

Ryan G. Etchison · University of Minnesota

Abstract

4EASO is a novel drug that causes apoptosis and selectively reduces eIF4E levels, eIF4F complex formation, and proliferation of mesothelioma cells. eIF4E knockdown results in decreased expression of anti-apoptotic and pro-growth proteins and enhances chemosensitivity.

Topics & Keywords

Polyamine Metabolism and Applications Cancer Research and Treatments Biopolymer Synthesis and Applications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 8, Issue 11, pp. e81669-e81669

DOI: 10.1371/journal.pone.0081669

Field-Weighted Citation Impact: 2.19