TOPAZ1, a Novel Germ Cell-Specific Expressed Gene Conserved during Evolution across Vertebrates

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Authors

Adrienne Baillet · École Nationale Vétérinaire d'Alfort

Ronan Le Bouffant · CEA Paris-Saclay - Etablissement de Fontenay-aux-roses

J.-N. Volff · École Normale Supérieure de Lyon

Alix Luangpraseuth · Laboratoire de Biologie du Développement

Elodie Poumerol · Laboratoire de Biologie du Développement

Dominique Thépot · Laboratoire de Biologie du Développement

Éric Pailhoux

Abstract

We have identified a novel PAZ-domain protein that is abundantly expressed in the gonads during germ cell meiosis. The expression pattern of TOPAZ1, and its high degree of conservation, suggests that it may play an important role in germ cell development. Further characterization of TOPAZ1 may elucidate the mechanisms involved in gametogenesis, and particularly in the RNA silencing process in the germ line.

Topics & Keywords

Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities Reproductive Biology and Fertility Animal Genetics and Reproduction

UN Sustainable Development Goals

Life in Land

Publication Details

Published in: PLoS ONE

Volume 6, Issue 11, pp. e26950-e26950

DOI: 10.1371/journal.pone.0026950

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