THE HUMAN CYP3A SUBFAMILY: PRACTICAL CONSIDERATIONS*

2000211 citationsReview

Authors

Steven Wrighton · Eli Lilly (United States)

Erin G. Schuetz · St. Jude Children's Research Hospital

Kenneth E. Thummel · University of Washington

Danny D. Shen · University of Washington

Kenneth R. Korzekwa · Campbell Institute

Paul B. Watkins · University of North Carolina at Chapel Hill

Abstract

The CYP3A subfamily of cytochromes P450 (CYP) in humans is composed of CYP3A4, 3A5, and 3A7. The CYP3A forms are involved in the metabolism of an amazingly large number of structurally diverse xeno...

Topics & Keywords

Pharmacogenetics and Drug Metabolism Drug Transport and Resistance Mechanisms Hormonal Regulation and Hypertension

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: Drug Metabolism Reviews

Volume 32, Issue 3-4, pp. 339-361

DOI: 10.1081/dmr-100102338

Field-Weighted Citation Impact: 7.79