Hydroxychloroquine concentration–response relationships in patients with rheumatoid arthritis

2002246 citationsJournal Article

Authors

Tino Münster · Friedrich-Alexander-Universität Erlangen-Nürnberg

John P. Gibbs · University of Washington

Danny D. Shen · University of Washington

Bruce A. Baethge · The University of Texas Medical Branch at Galveston

Gary R. Botstein

Jacques R. Caldwell

Fredrick Dietz · Rockford University

Robert E. Ettlinger

Abstract

There is a weak, but predictable, relationship between blood DHCQ concentrations and efficacy of treatment with HCQ. In addition, there is an association between gastrointestinal adverse events and elevated blood HCQ concentrations. Further investigation of these relationships is warranted to see if DHCQ may be introduced as a new antirheumatic drug.

Topics & Keywords

Drug-Induced Ocular Toxicity Rheumatoid Arthritis Research and Therapies Drug-Induced Hepatotoxicity and Protection

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Arthritis & Rheumatism

Volume 46, Issue 6, pp. 1460-1469

DOI: 10.1002/art.10307

Field-Weighted Citation Impact: 1.99