Comparing predictors of conversion and decline in mild cognitive impairment

2010612 citationsJournal Articlebronze Open Access

Authors

Susan Landau · Neurosciences Institute

Danielle Harvey · Neurosciences Institute

Catherine Madison · Neurosciences Institute

Eric M. Reiman · Neurosciences Institute

Norman L. Foster · Neurosciences Institute

Paul Aisen · Neurosciences Institute

Ronald C. Petersen ·

Abstract

Baseline FDG-PET and episodic memory predict conversion to AD, whereas p-tau(181p)/Abeta(1-42) and, marginally, FDG-PET predict longitudinal cognitive decline. Complementary information provided by these biomarkers may aid in future selection of patients for clinical trials or identification of patients likely to benefit from a therapeutic intervention.

Topics & Keywords

Dementia and Cognitive Impairment Research Alzheimer's disease research and treatments Functional Brain Connectivity Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neurology

Volume 75, Issue 3, pp. 230-238

DOI: 10.1212/wnl.0b013e3181e8e8b8

Field-Weighted Citation Impact: 33.47