Orchestration and Prognostic Significance of Immune Checkpoints in the Microenvironment of Primary and Metastatic Renal Cell Cancer

2015505 citationsJournal Articlehybrid Open Access

Authors

Nicolás A. Giraldo · Inserm

Étienne Becht · Inserm

Franck Pagès · Inserm

Georgios Skliris · Cubist Pharmaceuticals (United States)

Virginie Verkarre · Hôpital Necker-Enfants Malades

Yann Vano · Hôpital Européen

Arnaud Méjean · Hôpital Européen

Abstract

The expression of the immune checkpoints and the localization of DC in the tumor microenvironment modulate the clinical impact of CD8(+) T cells in ccRCC.

Topics & Keywords

Cancer Immunotherapy and Biomarkers Renal cell carcinoma treatment Bladder and Urothelial Cancer Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 21, Issue 13, pp. 3031-3040

DOI: 10.1158/1078-0432.ccr-14-2926

Field-Weighted Citation Impact: 12.50