Neurostimulation of the Cholinergic Anti-Inflammatory Pathway Ameliorates Disease in Rat Collagen-Induced Arthritis

2014197 citationsJournal Articlegold Open Access

Authors

Yaakov A. Levine · Alta Bates Summit Medical Center

Frieda A. Koopman · Academic Medical Center

Michael Faltys · Alta Bates Summit Medical Center

April S. Caravaca · Alta Bates Summit Medical Center

Alison M. Bendele · Bolder Biotechnology, Inc.

Ralph Zitnik · Alta Bates Summit Medical Center

Margriet J. Vervoordeldonk

Abstract

The severity of collagen-induced arthritis is reduced by neurostimulation of the cholinergic anti-inflammatory pathway delivered using an implanted electrical vagus nerve stimulation cuff electrode, and supports the rationale for testing this approach in human inflammatory disorders.

Topics & Keywords

Vagus Nerve Stimulation Research Nicotinic Acetylcholine Receptors Study Neuroscience and Neural Engineering

Publication Details

Published in: PLoS ONE

Volume 9, Issue 8, pp. e104530-e104530

DOI: 10.1371/journal.pone.0104530

Field-Weighted Citation Impact: 10.53

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Neurostimulation of the Cholinergic Anti-Inflammatory Pathway Ameliorates Disease in Rat Collagen-Induced Arthritis

Authors

Abstract

Topics & Keywords

Publication Details