Clinical aspects and cytokine response in severe H1N1 influenza A virus infection

2010225 citationsJournal Articlegold Open Access

Authors

Natalia Hagău · Spitalul Clinic Județean de Urgență Cluj-Napoca

Adriana Slavcovici · Spitalul Clinic CF Cluj-Napoca

Daniel N Gonganau · Spitalul Clinic Județean de Urgență Cluj-Napoca

Simona Oltean · Spitalul Clinic CF Cluj-Napoca

Dan Sebastian Dîrzu · Spitalul Clinic Județean de Urgență Cluj-Napoca

Erika S Brezoszki · Spitalul Clinic Județean de Urgență Cluj-Napoca

Mihaela Maxim

Abstract

In our critically ill patients with novel influenza A(H1N1) virus infection, the hallmarks of the severity of disease were IL-6, IL-15, IL-8 and TNFα. These cytokines, except TNFα, had a positive correlation with the admission delay and C-reactive protein, and a negative correlation with the PaO(2):FiO(2) ratio. Obese patients with nvA(H1N1) disease have a significant level of IL-8. There are significant differences in the level of cytokines when comparing viral ARDS with bacterial ARDS.

Topics & Keywords

Influenza Virus Research Studies Respiratory viral infections research Immune Response and Inflammation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Critical Care

Volume 14, Issue 6, pp. R203-R203

DOI: 10.1186/cc9324

Field-Weighted Citation Impact: 8.35