Engineered human mesenchymal stem cells: a novel platform for skeletal cell mediated gene therapy

2001216 citationsJournal Article

Authors

Gadi Turgeman · Hadassah Medical Center

Debbie D. Pittman

R. M�ller · Institute for Biomedical Engineering

Basan Gowda Kurkalli · Hadassah Medical Center

Shuanhu Zhou · Hadassah Medical Center

Gadi Pelled · Hebrew University of Jerusalem

Amos Peyser · Hebrew University of Jerusalem

Abstract

hMSCs represent a novel platform for skeletal gene therapy and the present results suggest that they can be genetically engineered to express desired therapeutic proteins inducing specific differentiation pathways. Moreover, hMSCs obtained from osteoporotic patients can restore their osteogenic activity following human BMP-2 gene transduction, an important finding in the future planning of gene therapy treatment for osteoporosis.

Topics & Keywords

Mesenchymal stem cell research Virus-based gene therapy research Pluripotent Stem Cells Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Gene Medicine

Volume 3, Issue 3, pp. 240-251

DOI: 10.1002/1521-2254(200105/06)3:3<240::aid-jgm181>3.0.co;2-a

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