Hyperferritinaemia in Dengue Virus Infected Patients Is Associated with Immune Activation and Coagulation Disturbances

201477 citationsJournal Articlegold Open Access

Authors

Cornelia A. M. van de Weg · Erasmus MC

Ralph Huits · University of Aruba

Cláudio Mendes Pannuti · Universidade de São Paulo

Rosalba M. Brouns · University of Aruba

Riemsdijk W. A. van den Berg · University of Aruba

Henk‐Jan van den Ham · Erasmus MC

B Martina ·

Abstract

Altogether, we provide evidence that ferritin can be used as a clinical marker to discriminate between dengue and other febrile illnesses. The occurrence of hyperferritinaemia in dengue virus infected patients is indicative for highly active disease resulting in immune activation and coagulation disturbances. Therefore, we recommend that patients with hyperferritinaemia are monitored carefully.

Topics & Keywords

Mosquito-borne diseases and control Autoimmune and Inflammatory Disorders Research Viral Infections and Vectors

UN Sustainable Development Goals

Reduced inequalities

Publication Details

Published in: PLoS neglected tropical diseases

Volume 8, Issue 10, pp. e3214-e3214

DOI: 10.1371/journal.pntd.0003214

Field-Weighted Citation Impact: 3.54