Immunological and Viral Determinants of Dengue Severity in Hospitalized Adults in Ha Noi, Viet Nam

201195 citationsJournal Articlegold Open Access

Authors

Annette Fox · University of Oxford

Le Nguyen Minh Hoa · Oxford University Clinical Research Unit

Cameron P. Simmons · Oxford University Clinical Research Unit

Marcel Wolbers · Oxford University Clinical Research Unit

Heiman Wertheim · Oxford University Clinical Research Unit

Pham Thi Khuong · Hospital for Tropical Diseases

Ninh Hai Thi Tran

Abstract

Dengue is emerging as a major public health problem in Ha Noi. DENV-1 and DENV-2 were the prevalent serotypes with similar numbers and clinical presentation. Secondary infection may be more common amongst DENV-2 than DENV-1 infections because DENV-2 infections resulted in lower plasma viral RNA concentrations and viral RNA concentrations were higher in secondary infection. The drivers of dengue emergence in northern Viet Nam need to be elucidated and public health measures instituted.

Topics & Keywords

Mosquito-borne diseases and control Viral Infections and Vectors Malaria Research and Control

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS neglected tropical diseases

Volume 5, Issue 3, pp. e967-e967

DOI: 10.1371/journal.pntd.0000967

Field-Weighted Citation Impact: 8.47