Common Genetic Variation in <i>KCNH2</i> Is Associated With QT Interval Duration

200795 citationsJournal Articlebronze Open Access

Authors

Christopher Newton‐Cheh · National Heart Lung and Blood Institute

Chao‐Yu Guo · National Heart Lung and Blood Institute

Martin G. Larson · Boston University

Stacy L. Musone · National Heart Lung and Blood Institute

Aarti Surti · Harvard University

Amy L. Camargo · Harvard University

Jared A. Drake

Abstract

Two common genetic variants at the KCNH2 locus are associated with continuous QT interval duration in an unselected community-based sample. Studies to determine the influence of these variants on risk of sudden cardiac death and drug-induced arrhythmias should be considered.

Topics & Keywords

Cardiac electrophysiology and arrhythmias Ion channel regulation and function Cardiac pacing and defibrillation studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 116, Issue 10, pp. 1128-1136

DOI: 10.1161/circulationaha.107.710780

Field-Weighted Citation Impact: 8.27